Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an
attractive drug target in numerous maladies that range from heart disease to …

Motivation Computational approaches for predicting drug–target interactions (DTIs) can
provide valuable insights into the drug mechanism of action. DTI predictions can help to …

Alzheimer's disease (AD) is a neurodegenerative disease that manifests its pathology
through synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal …

Mesenchymal stem cells (MSCs) protect tissues against cell death induced by
ischemia/reperfusion insults. This therapeutic effect seems to be controlled by physiological …

Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative
phosphorylation (OXPHOS) to fuel its growth; however, broadly inhibiting this pathway might …