Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The
understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral …

During the late stage of the viral life cycle, HIV-1 Gag assembles into a spherical immature
capsid, and undergoes budding, release, and maturation. Here we review events involved in …

The success of fluorescence experiments requires attention to experimental details and an
understanding of the instrumentation. There are also many potential artifacts that can distort …

The spread of HIV between immune cells is greatly enhanced by cell-cell adhesions called
virological synapses, although the underlying mechanisms have been unclear. With use of …

Observations of individual virions in live cells have led to the characterization of their
attachment, entry and intracellular transport. However, the assembly of individual virions has …

HIV-1 Gag drives a number of events during the genesis of virions and is the only viral
protein required for the assembly of virus-like particles in vitro and in cells. Although a …

Assembly and release of human immunodeficiency virus (HIV) occur at the plasma
membrane of infected cells and are driven by the Gag polyprotein. Previous studies …

The assembly of infectious human immunodeficiency virus (HIV) requires that Gag transport
and oligomerization be coordinated with its association with other viral proteins, viral RNAs …

The introduction of a label which can be detected in living cells opens new possibilities for
the direct analysis of dynamic processes in virus replication, such as the transport and …

Gag proteins direct the process of retroviral particle assembly and form the major protein
constituents of the viral core. The matrix region of the HIV-1 Gag polyprotein plays a critical …