Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia
Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective
R Nusslock, LB Alloy - Journal of affective disorders, 2017 - Elsevier
Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
A review of reward processing and motivational impairment in schizophrenia
This article reviews and synthesizes research on reward processing in schizophrenia, which
has begun to provide important insights into the cognitive and neural mechanisms …
has begun to provide important insights into the cognitive and neural mechanisms …
[HTML][HTML] Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment
MJ Millan, K Fone, T Steckler, WP Horan - European …, 2014 - Elsevier
Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …
at the time of the first psychotic episode of delusions and hallucinations. These positive …
The motivation and pleasure dimension of negative symptoms: neural substrates and behavioral outputs
A range of emotional and motivation impairments have long been clinically documented in
people with schizophrenia, and there has been a resurgence of interest in understanding …
people with schizophrenia, and there has been a resurgence of interest in understanding …
Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment.
One of the most debilitating aspects of schizophrenia is an apparent interest in or ability to
exert effort for rewards. Such “negative symptoms” may prevent individuals from obtaining …
exert effort for rewards. Such “negative symptoms” may prevent individuals from obtaining …
A new perspective on anhedonia in schizophrenia
GP Strauss, JM Gold - American Journal of Psychiatry, 2012 - Am Psychiatric Assoc
Objective: Previous research provides evidence for discrepancies in various types of
emotional self-report in individuals with schizophrenia; patients and healthy subjects report …
emotional self-report in individuals with schizophrenia; patients and healthy subjects report …
A transdiagnostic review of negative symptom phenomenology and etiology
GP Strauss, AS Cohen - Schizophrenia bulletin, 2017 - academic.oup.com
In the DSM5, negative symptoms are 1 of the 5 core dimensions of psychopathology
evaluated for schizophrenia. However, negative symptoms are not pathognomonic—they …
evaluated for schizophrenia. However, negative symptoms are not pathognomonic—they …
Emotion deficits in people with schizophrenia
AM Kring, O Elis - Annual review of clinical psychology, 2013 - annualreviews.org
Translational research on emotion in schizophrenia has revealed deficits in emotion
perception and expression, as well as intact areas, including emotional experience and …
perception and expression, as well as intact areas, including emotional experience and …
[HTML][HTML] Corticostriatal control of goal-directed action is impaired in schizophrenia
Background Goal-directed actions depend on our capacity to integrate the anticipated
consequences of an action with the value of those consequences, with the latter derived …
consequences of an action with the value of those consequences, with the latter derived …