In silico modelling of physiologic systems

RB Colquitt, DA Colquhoun, RH Thiele - Best practice & research Clinical …, 2011 - Elsevier
In silico modelling, in which computer models are developed to model a pharmacologic or
physiologic process, is a logical extension of controlled in vitro experimentation. It is the …

Left ventricular assist device management in the ICU

AK Pratt, NS Shah, SW Boyce - Critical care medicine, 2014 - journals.lww.com
Objectives: To review left ventricular assist device physiology, initial postoperative
management, common complications, trouble shooting and management of hypotension …

Simulation as a preoperative planning approach in advanced heart failure patients. A retrospective clinical analysis

M Capoccia, S Marconi, SA Singh, DM Pisanelli… - Biomedical engineering …, 2018 - Springer
Background Modelling and simulation may become clinically applicable tools for detailed
evaluation of the cardiovascular system and clinical decision-making to guide therapeutic …

Interactive simulator for e-Learning environments: a teaching software for health care professionals

C De Lazzari, I Genuini, DM Pisanelli… - BioMedical Engineering …, 2014 - Springer
There is an established tradition of cardiovascular simulation tools, but the application of this
kind of technology in the e-Learning arena is a novel approach. This paper presents an e …

ECMO Assistance during mechanical ventilation: Effects induced on energetic and haemodynamic variables

B De Lazzari, A Iacovoni, K Mottaghy… - Computer methods and …, 2021 - Elsevier
Abstract Background and Objective Simulation in cardiovascular medicine may help
clinicians understand the important events occurring during mechanical ventilation and …

CARDIOSIM©: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support

B De Lazzari, R Badagliacca, D Filomena, S Papa… - Bioengineering, 2022 - mdpi.com
This review is devoted to presenting the history of the CARDIOSIM© software simulator
platform, which was developed in Italy to simulate the human cardiovascular and respiratory …

[HTML][HTML] A numerical model applied to the simulation of cardiovascular hemodynamics and operating condition of continuous-flow left ventricular assist device

H Liu, S Liu, X Ma, Y Zhang - Mathematical Biosciences and …, 2020 - aimspress.com
The mathematical modeling of the cardiovascular system is a simple and noninvasive
method to comprehend hemodynamics and the operating mechanism of the mechanical …

Evaluation of different cannulation strategies for aortic arch surgery Using a cardiovascular numerical simulator

B De Lazzari, M Capoccia, NJ Cheshire… - Bioengineering, 2023 - mdpi.com
Aortic disease has a significant impact on quality of life. The involvement of the aortic arch
requires the preservation of blood supply to the brain during surgery. Deep hypothermic …

Decision-making in advanced heart failure patients requiring LVAD insertion: Can preoperative simulation become the way forward? A case study

M Capoccia, S Marconi, C De Lazzari - Journal of Biomedical …, 2018 - iris.uniroma1.it
Clinical practice heavily relies on results from randomized controlled trials, which may not
reflect completely individual patients. Patient-specific modelling has received increasing …

Mechanical ventilation and thoracic artificial lung assistance during mechanical circulatory support with PUCA pump: In silico study

C De Lazzari, I Genuini, B Quatember… - Computer methods and …, 2014 - Elsevier
Patients assisted with left ventricular assist device (LVAD) may require prolonged
mechanical ventilatory assistance secondary to postoperative respiratory failure. The goal of …