While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Aromatase inhibition is an efficient endocrine therapy to block ectopic estrogen production
for postmenopausal estrogen receptor (ER)-positive breast cancer patients, but many …

RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …

The biological functions of the epitranscriptomic modification N 6-methyladenosine (m 6 A)
in plants are not fully understood. CPSF30-L is a predominant isoform of the polyadenylation …

Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly
(A)) sites, alternative terminal exons account for much of the variation between human …

Human papillomaviruses (HPV) are a group of small non-enveloped DNA viruses whose
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …

Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …