Although the concept of chronic kidney disease (CKD) in children is similar to that in adults,
pediatric CKD has some peculiarities, and there is less evidence and many factors that are …

Kidney transplantation is the preferred treatment for pediatric end-stage renal disease
(ESRD). Preemptive transplantation avoids the increased morbidity and mortality of dialysis …

Background In clinical practice and clinical trials, changes in serum creatinine
concentrations are used to evaluate changes in kidney function. It has been assumed that …

Urinary epidermal growth factor (uEGF) has recently been identified as a promising
biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease …

Background: Due to the complexity of chronic kidney disease (CKD) pathophysiology,
biomarkers representing different mechanistic pathways have been targeted for the study …

Background At later stages of chronic kidney disease (CKD), a pattern of linear and
irreversible renal function decline is thought to be the most common. The objective of this …

Background Previous clinical studies of autosomal dominant polycystic kidney disease
(ADPKD) reported that loss of kidney function usually follows a steep and relentless course …

Background No randomized trials exist to guide the timing of the initiation of KRT in children.
We sought to define trends and predictors of the eGFR at initiation of KRT, center-related …

Background We practice the timely placement of an arteriovenous fistula (AVF) in patients
facing chronic hemodialysis. We have anecdotally observed after AVF creation that there …

Results Over a median follow-up of 9 years, 24.0% of participants experienced steady eGFR
decline, 25.9% had an unsteady decline, 25.6% were steady and stable, and 24.6% were …