High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …

The enhanced generation and accumulation of advanced glycation endproducts (AGEs)
have been linked to increased risk for macrovascular and microvascular complications …

High mobility group box 1 (HMGB1) protein, originally described as a DNA-binding protein
that stabilizes nucleosomes and facilitates transcription, can also be released extracellularly …

High-mobility group box 1 (HMGB1) is a nuclear factor that is released extracellularly as a
late mediator of lethality in sepsis as well as after necrotic, but not apoptotic, death. Here we …

The products of nonenzymatic glycation and oxidation of proteins and lipids, the advanced
glycation end products (AGEs), accumulate in a wide variety of environments. AGEs may be …

Pathogen-associated molecular patterns (PAMPs) and endogenous “danger” signals,
known as danger-associated molecular patterns (DAMPs), released from cells alert the …

The age-related neurodegenerative disorders such as Alzheimer's, Parkinson's, and
Huntington's diseases are characterized by the abnormal accumulation or aggregation of …

The receptor for advanced glycation end products (RAGE) is a central signaling molecule in
the innate immune system and is involved in the onset and sustainment of the inflammatory …

Advanced glycation end-products (AGEs) are an assorted group of molecules formed
through covalent bonds between a reduced sugar and a free amino group of proteins, lipids …

Diabetic neuropathy is the commonest form of peripheral neuropathy in the developed
countries of the world. In diabetic patients, the presence of peripheral neuropathy increases …