GABA A receptors are a heterogeneous family of ligand-gated ion channels responsible for
mediating inhibitory neurotransmission in the CNS. Since the identification of mammalian …

Two types of GABAA receptor-mediated inhibition (phasic and tonic) have been described in
cerebellar granule cells, although these cells receive GABAergic input only from a single cell …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

Recent advances in molecular biology and complementary information derived from
neuropharmacology, biochemistry and behavior have dramatically increased our …

The transmitter-gated ion channels mediate rapid synaptic transmission, for example, at the
neuromuscular junction using acetylcholine and in the CNS using primarily the amino acids …

GABAA receptors are the major inhibitory neurotransmitter receptors in the brain and are the
site of action of many clinically important drugs. These receptors are composed of five …

The ability of differing subunit combinations of γ-aminobutyric acid type A (GABA A)
receptors produced from murine α1, β2, and γ 2L subunits to form functional cell surface …

Cerebellar granule cells express six GABAA receptor subunits abundantly (α1, α6, β2, β3,
γ2, and δ) and assemble various pentameric receptor subtypes with unknown subunit …

The γ‐aminobutyric acid type A (GABAA) receptor represents an elementary switching
mechanism integral to the functioning of the central nervous system and a locus for the …

1. Patch‐clamp methods have been used to characterize GABA‐and glycine‐activated
channels and spontaneous synaptic currents in granule cells in thin cerebellar slices from 7 …