The coordination and timing of muscle activities during rhythmic movements, like walking
and swimming, are generated by intrinsic spinal motor circuits. Such locomotor networks are …

The spinal cord is home to the intrinsic networks for locomotion. An animal in which the
spinal cord has been fully severed from the brain can still produce rhythmic, patterned …

To define alterations of neuronal connectivity that occur during motor neuron degeneration,
we characterized the function and structure of spinal circuitry in spinal muscular atrophy …

Spinal cord interneurons play critical roles shaping motor output, but their precise identity
and connectivity remain unclear. Focusing on the V1 interneuron cardinal class we defined …

The ability to sense and move within an environment are complex functions necessary for
the survival of nearly all species. The spinal cord is both the initial entry site for peripheral …

Peripheral nerve injury induces permanent alterations in spinal cord circuitries that are not
reversed by regeneration. Nerve injury provokes the loss of many proprioceptive IA afferent …

Vertebrate movement is orchestrated by spinal inter-and motor neurons that, together with
sensory and cognitive input, produce dynamic motor behaviors. These behaviors vary from …

Motoneurons axotomized by peripheral nerve injuries experience profound changes in their
synaptic inputs that are associated with a neuroinflammatory response that includes local …

The spinal cord contains neuronal circuits termed Central Pattern Generators (CPGs) that
coordinate rhythmic motor activities. CPG circuits consist of motor neurons and multiple …

Spinal interneurons modulating motor output are highly diverse but surprisingly arise from
just a few embryonic subgroups. The principles governing their development, diversification …