Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug …
The platinum drug, cisplatin, is considered as among the most successful medications in
cancer treatment. However, due to its inherent toxicity and resistance limitations, research …
cancer treatment. However, due to its inherent toxicity and resistance limitations, research …
Unveiling the Effects of Copper Ions in the Aggregation of Amyloidogenic Proteins
V Oliveri - Molecules, 2023 - mdpi.com
Amyloid diseases have become a global concern due to their increasing prevalence.
Transition metals, including copper, can affect the aggregation of the pathological proteins …
Transition metals, including copper, can affect the aggregation of the pathological proteins …
Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease
The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple
pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and …
pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and …
Cu (II) Specifically Disassembles Insulin Amyloid Nanostructures via Direct Interaction with Cross-β Fibrils
In this work, we demonstrate direct evidence of the antiamyloid potential of Cu (II) ions
against amyloid formation of insulin. The Cu (II) ions were found to efficiently disassemble …
against amyloid formation of insulin. The Cu (II) ions were found to efficiently disassemble …
Exploration of Lycorine and Copper (II)'s Association with the N-Terminal Domain of Amyloid β
A Kola, G Vigni, D Valensin - Inorganics, 2023 - mdpi.com
Lycorine (LYC) is an active alkaloid first isolated from Narcissus pseudonarcissus and found
in most Amaryllidaceae plants. It belongs to the same family as galantamine, which is the …
in most Amaryllidaceae plants. It belongs to the same family as galantamine, which is the …
Catalytic function of zinc finger proteins against amyloid-amyloidogenesis
Zinc finger (ZF) proteins are integral to neurological processes by mediating biomolecular
interactions and regulating gene expression. Despite their implication in neurodegenerative …
interactions and regulating gene expression. Despite their implication in neurodegenerative …
Distinct aggregation and toxicity of N-terminally truncated Abeta4-42 over Abeta1-42 in the presence of Zn (II)
In the brains of Alzheimer's disease (AD) patients, the accumulation of amyloid-beta (Abeta)
aggregates is found. A peptides can be truncated at the Phe4 residue in the N-terminus …
aggregates is found. A peptides can be truncated at the Phe4 residue in the N-terminus …