HTLV-1 infection and adult T-cell leukemia/lymphoma—a tale of two proteins: tax and HBZ

CZ Giam, OJ Semmes - Viruses, 2016 - mdpi.com
HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that
currently infects 10–20 million people worldwide. While HTLV-1 infection is generally …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection

M de Marcken, K Dhaliwal, AC Danielsen… - Science …, 2019 - science.org
Human blood CD14+ monocytes are bone marrow–derived white blood cells that sense and
respond to pathogens. Although innate immune activation by RNA viruses preferentially …

Molecular mechanisms of HTLV-1 cell-to-cell transmission

C Gross, AK Thoma-Kress - Viruses, 2016 - mdpi.com
The tumorvirus human T-cell lymphotropic virus type 1 (HTLV-1), a member of the delta-
retrovirus family, is transmitted via cell-containing body fluids such as blood products …

NF‐κB signaling mechanisms in HTLV‐1‐induced adult T‐cell leukemia/lymphoma

EW Harhaj, CZ Giam - The FEBS journal, 2018 - Wiley Online Library
The human T‐cell leukemia virus type 1 (HTLV‐1) is a complex deltaretrovirus linked to
adult T‐cell leukemia/lymphoma (ATLL), a fatal CD 4+ malignancy in 3–5% of infected …

HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

Human T-cell leukaemia virus type 1: parasitism and pathogenesis

CRM Bangham, M Matsuoka - … Transactions of the …, 2017 - royalsocietypublishing.org
Human T-cell leukaemia virus type 1 (HTLV-1) causes not only adult T-cell leukaemia-
lymphoma (ATL), but also inflammatory diseases including HTLV-1-associated …

Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo

R Furuta, J Yasunaga, M Miura, K Sugata… - PLoS …, 2017 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) infects mainly CD4+ CCR4+ effector/memory T
cells in vivo. However, it remains unknown whether HTLV-1 preferentially infects these T …

NK cells and monocytes modulate primary HTLV-1 infection

R Moles, S Sarkis, V Galli, M Omsland, M Artesi… - PLoS …, 2022 - journals.plos.org
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1
infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type …

Inhibition of tunneling nanotube (TNT) formation and human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine

M Omsland, C Pise-Masison, D Fujikawa, V Galli… - Scientific Reports, 2018 - nature.com
The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell
interaction for transmission and productive infection. Cell-to-cell interactions through the …