Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

BACKGROUND AND PURPOSE Cannabidiol (CBD) and Δ9‐tetrahydrocannabinol (THC)
interact with transient receptor potential (TRP) channels and enzymes of the …

In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in
cancer patients. In order to effectively escape the tumour, enter the circulation and establish …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Through their capacity to sense danger signals and to generate active interleukin-1β (IL-1β),
inflammasomes occupy a central role in the inflammatory response. In contrast to IL-1β, little …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

The standard treatment for high-grade serous ovarian cancer is primary debulking surgery
followed by chemotherapy. The extent of metastasis and invasive potential of lesions can …