Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …

Background: Despite significant advancement in oncology research, cancer still poses one
of the leading causes of mortality worldwide. The increased incidences of cancer may be …

044disk doc..044disk chapter .. Page7 Page 1 Marine natural products D. John Faulkner
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA …

The oxazole is a five-membered aromatic heterocycle that contains both oxygen and
nitrogen. Oxazoles are numbered around the ring starting at the oxygen atom as shown …

Organobromine chemicals are produced naturally by an array of biological and other
chemical processes in our environment. Some of these compounds are identical to man …

A comprehensive overview of the use of NMR spectroscopy for chiral discrimination
Discrimination of Chiral Compounds Using NMR Spectroscopy concisely covers the broad …

The synthetic utility and potential power of the Diels–Alder (D–A) reaction in organic
chemistry is evident. These significances have been extended to the synthesis of a plethora …

Covering: up to the end of 2009 Over the last decade, dramatic improvements in mass-
sensitivity of NMR through low-volume tube probes and capillary probes, coupled with …

A highly convergent, stereocontrolled total synthesis of the potent antiproliferative agent (+)-
phorboxazole A (1) has been achieved. Highlights of the synthesis include: modified …

The synthesis of phorboxazole B has been accomplished in 27 linear steps and an overall
yield of 12.6%. The absolute stereochemistry of the C4− C12, C33− C38, and C13− C19 …