The outbreak of COVID-19 caused by SARS-CoV-2 is spreading worldwide, with the
pathogenesis mostly unclear. Both virus and host-derived microRNA (miRNA) play essential …

The exocyst, an octameric protein complex, is an essential component of the membrane
transport machinery required for tethering and fusion of vesicles at the plasma membrane …

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopment disorder resulting
from different etiological factors, both genetic and/or environmental. These factors can lead …

The appearance of SARS-CoV-2 in 2019 triggered a significant economic and health crisis
worldwide, with heterogeneous molecular mechanisms that contribute to its development …

The exocyst complex is an important regulator of intracellular trafficking and tethers
secretory vesicles to the plasma membrane. Understanding of its role in neuron outgrowth …

Cells comprise several intracellular membrane compartments that allow them to function
properly. One of these functions is cargo movement, typically proteins and membranes …

The highly conserved GTPase Cdc42 is an essential regulator of cell polarity and promotes
exocytosis through the exocyst complex in budding yeast and Drosophila. In mammals, this …

To assemble a brain, differentiating neurons must make proper connections and establish
specialized brain compartments. Abnormal levels of cell adhesion molecules disrupt these …

Background: The eukaryotic endomembrane system most likely arose via paralogous
expansions of genes encoding proteins that specify organelle identity, coat complexes and …

Pathological mutations in leucine-rich repeat kinase 2 (LRRK2) gene are the major genetic
cause of Parkinson's disease (PD). Multiple lines of evidence link LRRK2 to the control of …