Nicotinamide, a poly [ADP-ribose] polymerase 1 (PARP-1) inhibitor, as an adjunctive therapy for the treatment of Alzheimer's disease
F Salech, DP Ponce, AC Paula-Lima… - Frontiers in Aging …, 2020 - frontiersin.org
Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide
Adenine Dinucleotide (NAD) and has long been associated with neuronal development …
Adenine Dinucleotide (NAD) and has long been associated with neuronal development …
RyR-mediated calcium release in hippocampal health and disease
C Hidalgo, A Paula-Lima - Trends in Molecular Medicine, 2024 - cell.com
Hippocampal synaptic plasticity is widely considered the cellular basis of learning and
spatial memory processes. This article highlights the central role of Ca 2+ release from the …
spatial memory processes. This article highlights the central role of Ca 2+ release from the …
Alzheimer's Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent
J Díaz-Zúñiga, J More, S Melgar-Rodríguez… - Frontiers in …, 2020 - frontiersin.org
Periodontal disease is a disease of tooth-supporting tissues. It is a chronic disease with
inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota …
inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota …
Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers
Alzheimer's disease (AD) is characterized by the accumulation of soluble amyloid-β
oligomers (AβOs) in the brain, which disrupt synaptic function and promote cognitive …
oligomers (AβOs) in the brain, which disrupt synaptic function and promote cognitive …