Hepatic ischemia-reperfusion injury (IRI) is a multifactorial phenomenon which has been
associated with adverse clinical outcomes. IRI related tissue damage is characterized by …

Ex situ normothermic machine perfusion (NMP) might minimize ischemia/reperfusion injury
(IRI) of liver grafts. In this study, 20 primary liver transplantation recipients of older grafts (≥ …

In Italy, 20 minutes of a continuous flat line on an electrocardiogram are required for
declaration of death. In the setting of donation after circulatory death (DCD), prolonged warm …

Background The gold standard for organ preservation before transplantation is static cold
storage, which is unable to fully protect suboptimal livers from ischemia/reperfusion injury …

Background With the increased use of extended-criteria donors, static cold storage has
failed to provide optimal preservation of liver grafts, resulting in early allograft dysfunction …

Liver transplantation is the ultimate treatment option for end-stage liver failure. However,
liver graft injury remains a challenge. This study aimed to investigate the role of connexin32 …

Due to the shortage of liver allografts and the rising prevalence of fatty liver disease in the
general population, steatotic liver grafts are considered for transplantation. This condition is …

Abstract Purpose of Review Several pre-clinical studies have engineered nanoparticles for
immune regulation and have shown promising results in the fields of autoimmunity and …

Liver transplantation stands as the sole curative treatment for individuals suffering from end-
stage liver disease. Although tremendous progress has been made over the past years in …

The realm of extended criteria liver transplantation created the'adjacent possible'for dynamic
organ preservation. Machine perfusion of the liver greatly expanded donor organ …