Beyond binding: antibody effector functions in infectious diseases
LL Lu, TJ Suscovich, SM Fortune, G Alter - Nature Reviews Immunology, 2018 - nature.com
Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …
microorganisms or infected cells. Although preventing pathogen entry is one potential …
Engaging innate immunity in HIV-1 cure strategies
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells
SH Huang, Y Ren, AS Thomas, D Chan… - The Journal of …, 2018 - Am Soc Clin Investig
The presence of persistent, latent HIV reservoirs in CD4+ T cells obstructs current efforts to
cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by …
cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by …
Elimination of HIV-1-infected cells by broadly neutralizing antibodies
T Bruel, F Guivel-Benhassine, S Amraoui… - Nature …, 2016 - nature.com
The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for
suppressing viraemia, through mechanisms which remain poorly understood. Here, we …
suppressing viraemia, through mechanisms which remain poorly understood. Here, we …
Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs
I Sadowski, FB Hashemi - Cellular and Molecular Life Sciences, 2019 - Springer
Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …
deaths associated with this disease, significant effort is now directed towards the …
[HTML][HTML] Immunological approaches to HIV cure
Combination antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV)
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure
R Schober, B Brandus, T Laeremans… - Journal of Translational …, 2023 - Springer
Background Combination antiretroviral therapy (cART) has dramatically extended the life
expectancy of people living with HIV-1 and improved their quality of life. There is …
expectancy of people living with HIV-1 and improved their quality of life. There is …
[HTML][HTML] The potential of engineered antibodies for HIV-1 therapy and cure
M Grobben, RAL Stuart, MJ van Gils - Current opinion in virology, 2019 - Elsevier
Highlights•Therapy combining two or more antibodies show promising results in clinical
trials.•Fc domain engineering can improve antibody half-life and enhance effector …
trials.•Fc domain engineering can improve antibody half-life and enhance effector …
Co-receptor binding site antibodies enable CD4-mimetics to expose conserved anti-cluster A ADCC epitopes on HIV-1 envelope glycoproteins
Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to
conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody …
conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody …
Fighting HIV-1 persistence: At the crossroads of “shoc-K and B-Lock”
Despite the success of highly active antiretroviral therapy (HAART), integrated HIV-1 proviral
DNA cannot be eradicated from an infected individual. HAART is not able to eliminate …
DNA cannot be eradicated from an infected individual. HAART is not able to eliminate …