Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia
JE Rupert, A Narasimhan, DHA Jengelley… - Journal of Experimental …, 2021 - rupress.org
Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …
Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review
T Koltai, SJ Reshkin, TMA Carvalho, D Di Molfetta… - Cancers, 2022 - mdpi.com
Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …
The liver pre-metastatic niche in pancreatic cancer: A potential opportunity for intervention
P Gumberger, B Bjornsson, P Sandström, L Bojmar… - Cancers, 2022 - mdpi.com
Simple Summary Patients with pancreatic cancer have a very poor chance of long-term
survival. This is usually due to advanced disease at the time of diagnosis, which commonly …
survival. This is usually due to advanced disease at the time of diagnosis, which commonly …
Profiling of adipose and skeletal muscle in human pancreatic cancer cachexia reveals distinct gene profiles with convergent pathways
Simple Summary More than 80% of patients with pancreatic ductal adenocarcinoma (PDAC)
suffer cachexia, characterized by loss of muscle and fat. However, most cachexia studies …
suffer cachexia, characterized by loss of muscle and fat. However, most cachexia studies …
Hepatic signal transducer and activator of transcription‐3 signalling drives early‐stage pancreatic cancer cachexia via suppressed ketogenesis
PC Arneson‐Wissink, H Mendez, K Pelz… - Journal of Cachexia …, 2024 - Wiley Online Library
Background Patients with pancreatic ductal adenocarcinoma (PDAC) often suffer from
cachexia, a wasting syndrome that significantly reduces both quality of life and survival …
cachexia, a wasting syndrome that significantly reduces both quality of life and survival …
The role of interleukin-6/GP130 cytokines in cancer cachexia
DHA Jengelley, TA Zimmers - The Systemic Effects of Advanced Cancer: A …, 2022 - Springer
Cancer cachexia is characterized by the involuntary loss of skeletal muscle with or without
adipose tissue loss in the presence of tumor burden. It is a prevalent yet clinically unmet …
adipose tissue loss in the presence of tumor burden. It is a prevalent yet clinically unmet …
IL-6 trans-signaling and crosstalk among tumor, muscle and fat mediate pancreatic cancer cachexia
Most patients with pancreatic adenocarcinoma (PDAC) suffer unintentional weight loss, or
cachexia. Interleukin-6 causes cachexia in mice and associates with mortality in PDAC …
cachexia. Interleukin-6 causes cachexia in mice and associates with mortality in PDAC …
Profiling of matched adipose and skeletal muscle in human pancreatic cancer cachexia reveals distinct gene profiles with convergent pathways
The vast majority of patients with pancreatic ductal adenocarcinoma (PDAC) suffer cachexia.
Although cachexia results from concurrent loss of adipose and muscle tissue, most studies …
Although cachexia results from concurrent loss of adipose and muscle tissue, most studies …
[图书][B] Musculoskeletal Effects of Oncostatin M in Pancreatic Cancer Cachexia
DHA Jengelley - 2022 - search.proquest.com
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is the third leading cause of cancer-
related deaths with a five-year survival rate of 11%. PDAC tumors are characterized by a …
related deaths with a five-year survival rate of 11%. PDAC tumors are characterized by a …
An inflammatory subtype of pancreatic ductal adenocarcinoma is associated with poor prognosis and increased perioperative mortality
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by an aggressive
tumor behavior. The present analysis seeks to identify and analyze a cohort that meets …
tumor behavior. The present analysis seeks to identify and analyze a cohort that meets …