Neonicotinoids are a class of insecticides that exert their effect through a specific action on
neuronal nicotinic acetylcholine receptors (nAChRs). The success of these insecticides is …

Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic
targets for the treatment of pain and inflammation, but despite more than 30 years of …

Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are
considered less harmful than combustible cigarettes. However, limited research has been …

Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung
cancer. Several lines of evidence show that lung cancer cells express all of the proteins …

Neuroinflammation and cholinergic dysfunction, leading to cognitive impairment, are
hallmarks of aging and neurodegenerative disorders, including Alzheimer's disease (AD) …

CHRFAM7A is a relatively recent and exclusively human gene arising from the partial
duplication of exons 5 to 10 of the α7 neuronal nicotinic acetylcholine receptor subunit (α7 …

As a parasympathetic alkaloid and the main substance in cigarette smoke, nicotine
modulates the immune system, inhibits innate and acquired immunity and is used in treating …

The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
involved in the modulation of essential brain functions such as memory, learning, and …