Machine learning and artificial intelligence: a paradigm shift in big data-driven drug design and discovery

P Pasrija, P Jha, P Upadhyaya… - Current Topics in …, 2022 - benthamdirect.com
Background: The lengthy and expensive process of developing a novel medicine often takes
many years and entails a significant financial burden due to its poor success rate …

Label-free optical technologies to enhance noninvasive endoscopic imaging of early-stage cancers

S Chang, H Krzyzanowska… - Annual Review of …, 2024 - annualreviews.org
White light endoscopic imaging allows for the examination of internal human organs and is
essential in the detection and treatment of early-stage cancers. To facilitate diagnosis of …

Spectroscopic and histological evaluation of wound healing progression following Low Level Laser Therapy (LLLT)

V Prabhu, SBS Rao, S Chandra, P Kumar… - Journal of …, 2012 - Wiley Online Library
The present study focuses on the evaluation of the effect of He‐Ne laser on tissue
regeneration by monitoring collagen synthesis in wound granulation tissues in Swiss albino …

Multispectral fluorescence imaging of human ovarian and fallopian tube tissue for early-stage cancer detection

TH Tate, B Baggett, PFS Rice… - … of biomedical optics, 2016 - spiedigitallibrary.org
With early detection, 5-year survival rates for ovarian cancer exceed 90%, yet no effective
early screening method exists. Emerging consensus suggests over 50% of the most lethal …

Improving diagnosis of cervical pre-cancer: combination of PCA and SVM applied on fluorescence lifetime images

GR Sahoo, P Singh, K Pandey, C Kala, A Pradhan - Photonics, 2018 - mdpi.com
We report a significant improvement in the diagnosis of cervical cancer through a combined
application of principal component analysis (PCA) and support vector machine (SVM) on the …

Recent advances and the potential for clinical use of autofluorescence detection of extra-ophthalmic tissues

J Wizenty, T Schumann, D Theil, M Stockmann… - Molecules, 2020 - mdpi.com
The autofluorescence (AF) characteristics of endogenous fluorophores allow the label-free
assessment and visualization of cells and tissues of the human body. While AF imaging …

Nerve spectroscopy: understanding peripheral nerve autofluorescence through photodynamics

F Dip, R Aleman, M Socolovsky, N Villalba, J Falco… - Surgical …, 2021 - Springer
Background Being able to accurately identify sensory and motor nerves is crucial during
surgical procedures to prevent nerve injury. We aimed to (1) evaluate the feasibility of …

Probing nonenzymatic glycation of proteins by deep ultraviolet light emitting diode induced autofluorescence

DC Mukunda, VK Joshi, S Chandra… - International Journal of …, 2022 - Elsevier
The suitability of deep-UV-LED (285 nm) as an excitation source to induce autofluorescence
in nonenzymatically glycated proteins has been reported for the first time in this study. Non …

Ultraminiature optical design for multispectral fluorescence imaging endoscopes

TH Tate, M Keenan, J Black… - Journal of Biomedical …, 2017 - spiedigitallibrary.org
A miniature wide-field multispectral endoscopic imaging system was developed enabling
reflectance and fluorescence imaging over a broad wavelength range. At 0.8-mm diameter …

Morphologic three-dimensional scanning of fallopian tubes to assist ovarian cancer diagnosis

WJ Madore, E De Montigny… - Journal of …, 2017 - spiedigitallibrary.org
The majority of high-grade serous ovarian cancers is now believed to originate in the
fallopian tubes. Therefore, current practices include the pathological examination of excised …