Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

Mammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric
repeat–binding factors TRF1 and TRF2. Inhibition of TRF2 results in immediate deprotection …

To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA
component (mTR) was deleted from the mouse germline. mTR−/− mice lacked detectable …

The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here,
we show that the human telomeric protein TRF2 plays a key role in the protective activity of …

Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem
arrays of TTAGGG repeats bound to specific proteins. In normal human cells, telomeres …

Human telomeres are composed of long arrays of TTAGGG repeats that form a
nucleoprotein complex required for the protection and replication of chromosome ends. One …

Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence
(for example, TTAGGG in vertebrates 1). In most normal human cells, telomeres shorten with …

Telomerase-negative immortalized human cells maintain their telomeres by a mechanism
known as alternative lengthening of telomeres (ALT). We report here that ALT cells contain a …

Telomere length in human cells is controlled by a homeostasis mechanism that involves
telomerase and the negative regulator of telomere length, TRF1 (TTAGGG repeat binding …