System-level scenarios for the elucidation of T cell-mediated germinal center B cell differentiation
NJM Verstegen, V Ubels, HV Westerhoff… - Frontiers in …, 2021 - frontiersin.org
Germinal center (GC) reactions are vital to the correct functioning of the adaptive immune
system, through formation of high affinity, class switched antibodies. GCs are transient …
system, through formation of high affinity, class switched antibodies. GCs are transient …
B cell adapter for PI 3-kinase (BCAP) coordinates antigen internalization and trafficking through the B cell receptor
J Lagos, U Holder, S Sagadiev… - Science …, 2024 - science.org
B cell adapter for PI 3-kinase (BCAP) is an adaptor molecule associated with signaling
through multiple immune receptors, including the B cell receptor (BCR). However, B cell …
through multiple immune receptors, including the B cell receptor (BCR). However, B cell …
Minimalistic in vitro culture to drive human naive B cell differentiation into antibody-secreting cells
PPA Unger, NJM Verstegen, C Marsman, T Jorritsma… - Cells, 2021 - mdpi.com
High-affinity antibody-secreting cells (ASC) arise from terminal differentiation of B-cells after
coordinated interactions with T follicular helper (Tfh) cells in germinal centers (GC) …
coordinated interactions with T follicular helper (Tfh) cells in germinal centers (GC) …
The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor–Mediated HLA Class II Pathway
L Rijvers, MJ Melief, J van Langelaar… - The Journal of …, 2020 - journals.aai.org
Abstract C-type lectin CLEC16A is located next to CIITA, the master transcription factor of
HLA class II (HLA-II), at a susceptibility locus for several autoimmune diseases, including …
HLA class II (HLA-II), at a susceptibility locus for several autoimmune diseases, including …
[HTML][HTML] B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells
AR Minton, LD Smith, DJ Bryant… - … of targeted anti-tumor …, 2022 - ncbi.nlm.nih.gov
Aim: T-helper cells could play an important role in the pathogenesis of chronic lymphocytic
leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble …
leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble …
BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells
R Arthur, A Wathen, EA Lemm, FK Stevenson… - Cellular …, 2022 - Elsevier
BTK inhibitors (BTKi) have dramatically improved outcomes for patients with chronic
lymphocytic leukaemia (CLL) and some forms of B-cell lymphoma. However, new strategies …
lymphocytic leukaemia (CLL) and some forms of B-cell lymphoma. However, new strategies …
[PDF][PDF] Mikroskopické zobrazení fosfoinositidů v polarizovaných maligních B-buňkách
P Bačovská - is.muni.cz
Phosphoinositides are minor phospholipids contained in cell membranes, but they play a
major role in the physiological functioning of cellular processes and organelles. They are …
major role in the physiological functioning of cellular processes and organelles. They are …
[PDF][PDF] B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells
Aim: T-helper cells could play an important role in the pathogenesis of chronic lymphocytic
leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble …
leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble …
[PDF][PDF] Investigating the role of FAM83H, a protein mutated in Amelogenesis Imperfecta
T Tachie-Menson - 2020 - discovery.dundee.ac.uk
FAM83H is a member of the FAM83 (Family with sequence similarity 83) protein family, a
family of eight members (FAM83A-FAM83H) that is conserved in vertebrates ( Figure 1-1) …
family of eight members (FAM83A-FAM83H) that is conserved in vertebrates ( Figure 1-1) …