Kidney stone disease (nephrolithiasis) is a common problem that can be associated with
alterations in urinary solute composition including hypercalciuria. Studies suggest that the …

Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological
processes and are implicated in numerous human diseases. Advances in structural biology …

Kidney stone disease is a complex disorder with a strong genetic component. We conducted
a genome-wide association study of 28.3 million sequence variants detected through whole …

The role of the kidney in calcium homeostasis has been reshaped from a classic view in
which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or …

Renal stone disease is a frequent condition, causing a huge burden on health care systems
globally. Calcium-based calculi account for around 75% of renal stone disease and the …

This chapter reviews the physiological and pathological roles of TRPV5 and TRPV6 and
discusses a variety of techniques that have led to a deeper understanding of these …

Kidney stone disease is a common disorder in Western countries that is associated with
significant suffering, morbidity, and cost for the healthcare system. Numerous studies have …

TRPV5 is one of the two channels in the TRPV family that exhibit high selectivity to Ca 2+
ions. TRPV5 mediates Ca 2+ influx into cells as the first step to transport Ca 2+ across …

Introduction B-cell activation triggers the release of endoplasmic reticulum calcium stores
through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by …

Background Treatment with the aminoglycoside antibiotic gentamicin can be associated with
severe adverse effects, including renal Ca 2+ wasting. The underlying mechanism is …