The impact of HIV-and ART-induced mitochondrial dysfunction in cellular senescence and aging

M Schank, J Zhao, JP Moorman, ZQ Yao - Cells, 2021 - mdpi.com
According to the WHO, 38 million individuals were living with human immunodeficiency virus
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …

Specific biological features of adipose tissue, and their impact on HIV persistence

C Bourgeois, J Gorwood, A Barrail-Tran… - Frontiers in …, 2019 - frontiersin.org
Although white AT can contribute to anti-infectious immune responses, it can also be
targeted and perturbed by pathogens. The AT's immune involvement is primarily due to …

Hallmarks of metabolic reprogramming and their role in viral pathogenesis

CNS Allen, SP Arjona, M Santerre, BE Sawaya - Viruses, 2022 - mdpi.com
Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral
infections. Metabolic reprogramming provides the cell with energy and biomass for large …

Neuroinflammation in HIV-associated depression: Evidence and future perspectives

A Mudra Rakshasa-Loots, HC Whalley, JH Vera… - Molecular …, 2022 - nature.com
People living with HIV face a high risk of mental illness, especially depression. We do not yet
know the precise neurobiological mechanisms underlying HIV-associated depression …

Cerebral vascular toxicity of antiretroviral therapy

L Bertrand, M Velichkovska, M Toborek - Journal of neuroimmune …, 2021 - Springer
HIV infection is associated with comorbidities that are likely to be driven not only by HIV
itself, but also by the toxicity of long-term use of antiretroviral therapy (ART). Indeed …

ROS-induced mitochondrial dysfunction in CD4 T cells from ART-controlled people living with HIV

M Schank, J Zhao, L Wang, LNT Nguyen, Y Zhang… - Viruses, 2023 - mdpi.com
We have previously demonstrated mitochondrial dysfunction in aging CD4 T cells from
antiretroviral therapy (ART)-controlled people living with HIV (PLWH). However, the …

Effectiveness of financial incentives in achieving UNAID fast-track 90-90-90 and 95-95-95 target of HIV care continuum: a systematic review and meta-analysis of …

Y Krishnamoorthy, T Rehman, M Sakthivel - AIDS and Behavior, 2021 - Springer
Financial incentives influence behavioural changes and the current review was done to
assess the effectiveness of this intervention in improving HIV care continuum. We conducted …

Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection

W Mu, V Patankar, S Kitchen, A Zhen - Viruses, 2024 - mdpi.com
Chronic Human Immunodeficiency Virus (HIV) infection remains a significant challenge to
global public health. Despite advances in antiretroviral therapy (ART), which has …

HIV-Associated Hypertension: Risks, Mechanisms, and Knowledge Gaps

P Prakash, BS Swami Vetha, R Chakraborty… - Circulation …, 2024 - Am Heart Assoc
HIV type 1 (HIV-1) is the causative agent of AIDS. Since the start of the epidemic, HIV/AIDS
has been responsible for≈ 40 million deaths. Additionally, an estimated 39 million people …

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical …

H Mataramvura, MJ Bunders, K Duri - Frontiers in immunology, 2023 - frontiersin.org
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis
(Option B+) has dramatically improved the health of HIV-infected women and their children …