Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

MK Jolly, JA Somarelli, M Sheth, A Biddle… - Pharmacology & …, 2019 - Elsevier
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Through the glass darkly: intraepithelial neoplasia, top‐down differentiation, and the road to ovarian cancer

CP Crum, M Herfs, G Ning, JG Bijron… - The Journal of …, 2013 - Wiley Online Library
It is currently hoped that deaths from extra‐uterine high‐grade serous cancer (HGSC) will be
reduced via opportunistic salpingectomy in healthy women. Accumulated data implicate the …

miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin

X Zhu, H Shen, X Yin, L Long, C Xie, Y Liu, L Hui, X Lin… - Oncogene, 2016 - nature.com
Epithelial–mesenchymal transition (EMT) has an established role in promoting tumor
progression and the acquisition of therapeutic resistance. Here, the EMT phenotype was …

The long noncoding RNA TTTY15, which is located on the Y chromosome, promotes prostate cancer progression by sponging let-7

J Yao, D Kong, C Ye, R Chen, L Li, T Zeng, L Wang… - European urology, 2019 - Elsevier
Background The link between prostate cancer (PCa) development and aberrant expression
of genes located on the Y chromosome remains unclear. Objective To identify Y …

Single-cell transcriptomics in ovarian cancer identify a metastasis-associated cell cluster overexpressed RAB13

J Guo, X Han, J Li, Z Li, J Yi, Y Gao, X Zhao… - Journal of Translational …, 2023 - Springer
Background Metastasis, the leading cause of cancer-related death in patients diagnosed
with ovarian cancer (OC), is a complex process that involves multiple biological effects. With …

[HTML][HTML] RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis

Y Huang, M Zhao, H Xu, K Wang, Z Fu, Y Jiang, Z Yao - Oncotarget, 2014 - ncbi.nlm.nih.gov
Ovarian cancer is the most lethal gynecologic malignancy, and transcoelomic metastasis is
responsible for the greatest disease mortality. Although intensive efforts have been made …

Parametric analysis of colony morphology of non-labelled live human pluripotent stem cells for cell quality control

R Kato, M Matsumoto, H Sasaki, R Joto, M Okada… - Scientific reports, 2016 - nature.com
Given the difficulties inherent in maintaining human pluripotent stem cells (hPSCs) in a
healthy state, hPSCs should be routinely characterized using several established standard …

Establishment of an ovarian cancer omentum metastasis-related prognostic model by integrated analysis of scRNA-seq and bulk RNA-seq

D Zhang, W Lu, S Cui, H Mei, X Wu, Z Zhuo - Journal of Ovarian Research, 2022 - Springer
Objective Ovarian cancer has the highest mortality rate among gynecological malignant
tumors, and it preferentially metastasizes to omental tissue, leading to intestinal obstruction …

[HTML][HTML] Association of preoperative aspartate aminotransferase to platelet ratio index with outcomes and tumour microenvironment among colorectal cancer with liver …

Q Chen, Y Deng, Y Li, J Chen, R Zhang, L Yang, R Guo… - Cancer Letters, 2024 - Elsevier
This study aims to investigate applicable robust biomarkers that can improve prognostic
predictions for colorectal liver metastasis (CRLM) patients receiving simultaneous resection …

Lysophosphatidic acid initiates epithelial to mesenchymal transition and induces β-catenin-mediated transcription in epithelial ovarian carcinoma

RJ Burkhalter, SD Westfall, Y Liu, MS Stack - Journal of Biological …, 2015 - ASBMB
During tumor progression, epithelial ovarian cancer (EOC) cells undergo epithelial-to-
mesenchymal transition (EMT), which influences metastatic success. Mutation-dependent …