Signal transduction is initiated by complex protein–protein interactions between ligands,
receptors and kinases, to name only a few. It is now becoming clear that lipid micro …

Nonstandard abbreviations used: glycophosphatidylinositolanchored (GPI-anchored);
endothelial nitric oxide synthase (eNOS); β-secretase (BACE); endoplasmic reticulum (ER); …

One key tenet of the raft hypothesis is that the formation of glycosphingolipid-and cholesterol-
rich lipid domains can be driven solely by characteristic lipid-lipid interactions, suggesting …

Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

The FcεRI complex forms a high-affinity cell-surface receptor for the Fc region of antigen-
specific immunoglobulin E (IgE) molecules. FcεRI is multimeric and is a member of a family …

Biochemical and cell-biological experiments have identified cholesterol as an important
component of lipid 'rafts' and related structures (eg, caveolae) in mammalian cell …

Plasma membrane compartments, delimited by transmembrane proteins anchored to the
membrane skeleton (anchored-protein picket model), would provide the membrane with …

There is overwhelming evidence that lipid bilayer regions of animal cell membranes are in a
liquid state. Quantitative models of these bilayer regions must then be models of liquids …

The cells of both the adaptive and innate immune systems express a dizzying array of
receptors that transduce and integrate an enormous amount of information about the …

Phospholipid vesicles exhibit a natural tendency to fuse and assemble into a continuous
single bilayer membrane on silica and several other substrate materials. The resulting …