Nonribosomal peptide synthesis—principles and prospects
RD Süssmuth, A Mainz - Angewandte Chemie International …, 2017 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …
assemble numerous peptides with large structural and functional diversity. These peptides …
Biological activity of lipopeptides from Bacillus
H Zhao, D Shao, C Jiang, J Shi, Q Li, Q Huang… - Applied microbiology …, 2017 - Springer
The lipopeptides of Bacillus are small metabolites that contain a cyclic structure formed by 7–
10 amino acids (including 2–4 d-amino acids) and a beta-hydroxy fatty acid with 13–19 C …
10 amino acids (including 2–4 d-amino acids) and a beta-hydroxy fatty acid with 13–19 C …
Natural functions of lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics
JM Raaijmakers, I De Bruijn, O Nybroe… - FEMS microbiology …, 2010 - academic.oup.com
Lipopeptides constitute a structurally diverse group of metabolites produced by various
bacterial and fungal genera. In the past decades, research on lipopeptides has been fueled …
bacterial and fungal genera. In the past decades, research on lipopeptides has been fueled …
The role of dynamic conformational ensembles in biomolecular recognition
Molecular recognition is central to all biological processes. For the past 50 years,
Koshland's' induced fit'hypothesis has been the textbook explanation for molecular …
Koshland's' induced fit'hypothesis has been the textbook explanation for molecular …
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis
RF Little, C Hertweck - Natural Product Reports, 2022 - pubs.rsc.org
Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …
natural products is strongly influenced by how they are released from their biosynthetic …
Nonribosomal peptide synthetases: structures and dynamics
M Strieker, A Tanović, MA Marahiel - Current opinion in structural biology, 2010 - Elsevier
Nonribosomal peptide synthetases (NRPSs) are large multimodular biocatalysts that utilize
complex regiospecific and stereospecific reactions to assemble structurally and functionally …
complex regiospecific and stereospecific reactions to assemble structurally and functionally …
Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase
AM Gulick - ACS chemical biology, 2009 - ACS Publications
The ANL superfamily of adenylating enzymes contains acyl-and aryl-CoA synthetases, firefly
luciferase, and the adenylation domains of the modular non-ribosomal peptide synthetases …
luciferase, and the adenylation domains of the modular non-ribosomal peptide synthetases …
The structural biology of biosynthetic megaenzymes
KJ Weissman - Nature Chemical Biology, 2015 - nature.com
The modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs)
are among the largest and most complicated enzymes in nature. In these biosynthetic …
are among the largest and most complicated enzymes in nature. In these biosynthetic …
Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology
GH Hur, CR Vickery, MD Burkart - Natural product reports, 2012 - pubs.rsc.org
Covering up to the end of 2011 Many pharmaceuticals on the market today belong to a large
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …