In the central nervous system, oligodendrocytes produce myelin sheaths that enwrap
neuronal axons to provide trophic support and increase conduction velocity. New …

With the deepening of population aging, the treatment of cognitive impairment and dementia
is facing increasing challenges. Vascular dementia (VaD) is a cognitive dysfunction caused …

Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction
of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to …

Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-
autonomous loss of individual genes can result in different regional phenotypes. However, a …

In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and
subsequent neuronal degeneration throughout the CNS impair patient functionality. While …

Oligodendrocytes are highly specialized glial cells, responsible for producing myelin in the
central nervous system (CNS). The multi-stage process of oligodendrocyte development is …

Myelination has evolved as a mechanism to ensure fast and efficient propagation of nerve
impulses along axons. Within the central nervous system (CNS), myelination is carried out …

During differentiation, oligodendrocyte precursor cells (OPCs) extend a network of
processes that make contact with axons and initiate myelination. Recent studies revealed …

Introduction Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and
neurodegenerative condition affecting the central nervous system (CNS). Although …

Multiple sclerosis is an autoimmune neurodegenerative disease of the CNS that causes
progressive disabilities, owing to CNS axon degeneration as a late result of demyelination …