Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence

AM Traish, AT Guay - The journal of sexual medicine, 2006 - academic.oup.com
Androgens are deemed critical for penile‐tissue development, growth, and maintenance of
erectile function, however, their role in erection, especially in humans, remains controversial …

Amelioration of penile fibrosis: myth or reality

AI El‐Sakka, AA Yassin - Journal of Andrology, 2010 - Wiley Online Library
Several changes have been reported to occur in the cavernosal tissue and tunica albuginea
with aging. The atherosclerosis of the penis that occurs with aging causes a decrease in …

Chronic daily tadalafil prevents the corporal fibrosis and veno‐occlusive dysfunction that occurs after cavernosal nerve resection

I Kovanecz, A Rambhatla, MG Ferrini… - BJU …, 2008 - Wiley Online Library
Associate Editor Michael G. Wyllie Editorial Board Ian Eardley, UK Jean Fourcroy, USA
Sidney Glina, Brazil Julia Heiman, USA Chris McMahon, Australia Bob Millar, UK Alvaro …

A morphometric analysis of bulbar urethral strictures

AG Cavalcanti, WS Costa, LS Baskin… - BJU …, 2007 - Wiley Online Library
In a beautifully descriptive paper, authors from Rio de Janeiro and San Francisco report a
quantitative and qualitative histological analysis of spongiosal tissue in patients with bulbar …

Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats

X Qiu, H Lin, Y Wang, W Yu, Y Chen… - The journal of sexual …, 2011 - academic.oup.com
Introduction Erectile dysfunction (ED) is a frequent complication of diabetes mellitus. The
efficacy of common ED therapies is low for diabetes-associated ED. Aim To explore the …

Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats

I Kovanecz, A Rambhatla, M Ferrini, D Vernet… - International journal of …, 2008 - nature.com
It was recently reported in the rat that vardenafil given in a continuous long-term manner was
successful in preventing smooth muscle fibrosis in the penile corpora cavernosa and …

Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat

MG Ferrini, I Kovanecz, S Sanchez… - Biology of …, 2007 - academic.oup.com
Aging-related erectile dysfunction is characterized by a loss of smooth muscle cells (SMCs)
and fibrosis in the corpora cavernosa, and functionally by corporal veno-occlusive …

Effect of muscle‐derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat

G Nolazco, I Kovanecz, D Vernet, RA Gelfand… - BJU …, 2008 - Wiley Online Library
OBJECTIVE To determine whether skeletal muscle‐derived stem cells (MDSCs) convert into
smooth muscle cells (SMCs) both in vitro and in vivo, and in so doing ameliorate the erectile …

Combined strategy of mesenchymal stem cell injection with vascular endothelial growth factor gene therapy for the treatment of diabetes‐associated erectile …

X Qiu, C Sun, W Yu, H Lin, Z Sun, Y Chen… - Journal of …, 2012 - Wiley Online Library
This study was designed to investigate the effect of vascular endothelial growth factor 164
adenovirus (Ad‐VEGF164)–transfected mesenchymal stem cells (MSC) on improving …

Testosterone undecanoate restores erectile function in a subset of patients with venous leakage: a series of case reports

AA Yassin, F Saad, A Traish - The journal of sexual medicine, 2006 - academic.oup.com
Introduction Androgens are critical for maintaining penile structure and function and
androgen deficiency alters the function of the corporal veno‐occlusive mechanism in animal …