The etiology of most neurodegenerative disorders is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. The role of pesticide …

Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …

Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of
Parkinson's disease. Although the intensely anionic C-terminal domain (CTD) of αSN does …

Synucleinopathies, such as Parkinson's disease and diffuse Lewy body disease, are
progressive neurodegenerative disorders characterized by selective neuronal death …

Neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and …

Multiple system atrophy (MSA) is a fatal adult‐onset neurodegenerative disorder of
uncertain etiology, clinically manifesting with autonomic failure associated with …

Parkinson's disease (PD) is characterized by the presence of inclusions known as Lewy
bodies, which mainly consist of α-synuclein (α-syn) aggregates. There is growing evidence …

Misfolding and aggregation of the proteins amyloid‐β, tau and alpha‐synuclein is the
predominant pathology underlying the neurodegenerative disorders, Alzheimer's and …

Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder typified by tremor, rigidity, akinesia and postural instability due in part to the loss of …

Oligomeric forms of amyloid aggregates have been detected in the brains and tissues of
patients suffering from neurodegenerative disorders such as Parkinson's disease, and it is …