Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …

The cerebellum and its thalamic projections to the primary motor cortex (M1) are well known
to play an essential role in executing daily actions. Anatomic investigations in animals and …

Importance It remains unclear why lesions in some locations cause epilepsy while others do
not. Identifying the brain regions or networks associated with epilepsy by mapping these …

Additional treatment options for temporal lobe epilepsy are needed, and potential
interventions targeting the cerebellum are of interest. Previous animal work has shown …

Approximately 1 in 26 people will develop epilepsy in their lifetime, but current treatment
options leave as many as half of all epilepsy patients with uncontrolled seizures. In addition …

Despite being canonically considered a motor control structure, the cerebellum is
increasingly recognized for important roles in processes beyond this traditional framework …

Background: Epilepsy is a widespread neurologic disorder and almost one-third of patients
suffer from drug-resistant epilepsy (DRE). Neuromodulation targeting the …

Absence seizures (ASs) are characterized by pathological electrographic oscillations in the
cerebral cortex and thalamus, which are called spike-and-wave discharges (SWDs) …

Highlights•The cerebellum may be a potential target for therapeutic intervention in
epilepsy.•Modulation of cerebellar neurons can attenuate seizures in animal models of …

(1) Objective: Resting-state fMRI studies have indicated that juvenile myoclonic epilepsy
(JME) could cause widespread functional connectivity disruptions between the cerebrum …