Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

The GABAA receptor as a therapeutic target for neurodevelopmental disorders

S Braat, RF Kooy - Neuron, 2015 - cell.com
Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …

GABA system dysfunction in autism and related disorders: from synapse to symptoms

S Coghlan, J Horder, B Inkster, MA Mendez… - Neuroscience & …, 2012 - Elsevier
Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by
repetitive behaviours and restricted interests, impairments in social behaviour and relations …

GABAergic system dysfunction in autism spectrum disorders

H Zhao, X Mao, C Zhu, X Zou, F Peng… - Frontiers in cell and …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) refers to a series of neurodevelopmental diseases
characterized by two hallmark symptoms, social communication deficits and repetitive …

Neuronal activity–regulated gene transcription in synapse development and cognitive function

AE West, ME Greenberg - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Activity-dependent plasticity of vertebrate neurons allows the brain to respond to its
environment. During brain development, both spontaneous and sensory-driven neural …

GABAergic signaling as therapeutic target for autism spectrum disorders

G Cellot, E Cherubini - Frontiers in pediatrics, 2014 - frontiersin.org
γ-Aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, early in
postnatal life exerts a depolarizing and excitatory action. This depends on accumulation of …

Distinct thalamic reticular cell types differentially modulate normal and pathological cortical rhythms

A Clemente-Perez, SR Makinson, B Higashikubo… - Cell reports, 2017 - cell.com
Integrative brain functions depend on widely distributed, rhythmically coordinated
computations. Through its long-ranging connections with cortex and most senses, the …

Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

G Deidda, IF Bozarth, L Cancedda - Frontiers in cellular neuroscience, 2014 - frontiersin.org
During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …

Mechanisms of specificity in neuronal activity-regulated gene transcription

MR Lyons, AE West - Progress in neurobiology, 2011 - Elsevier
The brain is a highly adaptable organ that is capable of converting sensory information into
changes in neuronal function. This plasticity allows behavior to be accommodated to the …

Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome

KE Carstens, DJ Lustberg… - The Journal of …, 2021 - Am Soc Clin Investig
Perineuronal nets (PNNs), a specialized form of extracellular matrix, are abnormal in the
brains of people with Rett syndrome (RTT). We previously reported that PNNs function to …