The biggest compartment of the musculoskeletal system is the tendons and ligaments. In
particular, tendons are dense tissues connecting muscle to bone that are critical for the …

Adult-acquired flatfoot deformity (AAFD) comprises a wide spectrum of ligament and tendon
failure that may result in significant deformity and disability. It is often associated with …

Adult-Acquired Flatfoot Deformity: Etiology, Diagnosis, and... : JBJS Reviews Adult-Acquired
Flatfoot Deformity: Etiology, Diagnosis, and Management : JBJS Reviews JBJS Journal Case …

Degenerative orthopedic diseases, as a global public health problem, have made serious
negative impact on patients' quality of life and socio-economic burden. Traditional …

There is mounting evidence suggesting a genetic contribution to the susceptibility of
sustaining a musculoskeletal soft-tissue injury. To date, more than 70 loci have been …

Objectives Anterior cruciate ligament rupture (ACLR) is a common and severe knee injury
which typically occurs as a result of sports participation, primarily via a non-contact …

Posterior tibial tendinopathy (PTT) can lead to acquired flatfoot in adults. Many patients
develop PTT without any identifiable risk factors. Molecular changes in extracellular matrix …

Posterior tibial tendon (PTT) dysfunction is recognized as an etiology leading to acquired
flatfoot in adults, causing significant functional loss. Many risk factors and systemic …

Progressive collapsing foot deformity (PCFD) is one of the most controversial topics in foot
and ankle surgery. Reviews normally focus on different surgical approaches depending on …

To date, more than 18 genomic intervals, which underpin the complex myriad of extracellular
matrix interactions of tendons, have been implicated in risk models for tendinopathy. It is …