Microglia morphological categorization in a rat model of neuroinflammation by hierarchical cluster and principal components analysis

MM Fernández-Arjona, JM Grondona… - Frontiers in cellular …, 2017 - frontiersin.org
It is known that microglia morphology and function are closely related, but only few studies
have objectively described different morphological subtypes. To address this issue …

Microglia function on precursor cells in the adult hippocampus and their responsiveness to serotonin signaling

A Turkin, O Tuchina, F Klempin - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Microglia are the resident immune cells of the adult brain that become activated in response
to pathogen-or damage-associated stimuli. The acute inflammatory response to injury …

Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states

D Carvalho-Paulo, J Bento Torres Neto… - Frontiers in …, 2021 - frontiersin.org
Microglial immunosurveillance of the brain parenchyma to detect local perturbations in
homeostasis, in all species, results in the adoption of a spectrum of morphological changes …

Microglial morphometric parameters correlate with the expression level of IL-1β, and allow identifying different activated morphotypes

MM Fernández-Arjona, JM Grondona… - Frontiers in cellular …, 2019 - frontiersin.org
Microglia are the resident macrophages in the brain. Traditionally, two forms of microglia
have been described: one considered as a resting/surveillant state in which cells have a …

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

W Wu, S He, J Wu, C Chen, X Li, K Liu, JY Qu - Nature communications, 2022 - nature.com
The spinal cord accounts for the main communication pathway between the brain and the
peripheral nervous system. Spinal cord injury is a devastating and largely irreversible …

Microglia morphotyping in the adult mouse CNS using hierarchical clustering on principal components reveals regional heterogeneity but no sexual dimorphism

HRJ van Weering, TW Nijboer, ML Brummer… - Glia, 2023 - Wiley Online Library
Microglia are the resident macrophages of the central nervous system (CNS) and play a
pivotal role in immune surveillance and CNS homeostasis. Morphological transitions in …

[HTML][HTML] Long-term environmental enrichment affects microglial morphology in middle age mice

S Ali, X Liu, NJ Queen, RS Patel, RK Wilkins… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Aging is associated with increased central nervous system inflammation, in large part due to
dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the …

In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons

W Wu, Y He, Y Chen, Y Fu, S He, K Liu… - Nature communications, 2024 - nature.com
Microglia, the primary immune cells in the central nervous system, play a critical role in
regulating neuronal function and fate through their interaction with neurons. Despite …

Comparative morphometric analysis of microglia in the spinal cord of SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis

T Ohgomori, J Yamada, H Takeuchi… - European Journal of …, 2016 - Wiley Online Library
It has long been recognized that reactive microglia undergo a series of phenotypic changes
accompanying morphological transformation. However, the morphological classification of …

Long‐term environmental enrichment reduces microglia morphological diversity of the molecular layer of dentate gyrus

TCG de Oliveira, D Carvalho‐Paulo… - European Journal of …, 2020 - Wiley Online Library
We investigated long‐term environmental influences on morphology of microglia from the
outer and middle thirds of molecular layer of the dentate gyrus (MolDG), and on microglia …