Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the
pharmaceutical sciences. We summarize successful fragment-to-lead studies that were …

Although fragment-based drug discovery (FBDD) has been successfully implemented and
well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the …

Nucleic acids play crucial roles in transferring cellular information and gene regulations.
DNA and RNA molecules have been associated with multiple human diseases and thus …

The majority of antivirals available target viral proteins; however, RNA is emerging as a new
and promising antiviral target due to the presence of highly structured RNA in viral genomes …

Antibiotic resistance is rapidly evolving at an alarming rate, posing a severe threat to
humanity. In an effort to develop compounds with antimicrobial activity, we synthesized a …

RNA structures, including those formed from coding and noncoding RNAs, alternative to
protein‐based drug targets, could be a promising target of small molecules for drug …

A series of Cu (II) complexes, 1–4 and 6, were synthesized through a reaction of amine-
functionalized pincer-like ligands, HL 1, 2, L a, b, and a bidentate ligand L 1 with CuCl2 …

HIV-1 remains a global health concern and to date, nearly 38 million people are living with
HIV. The complexity of HIV-1 pathogenesis and its subsequent prevalence is influenced by …

Bioorthogonal chemistry is a rapidly expanding field of research that involves the use of
small molecules that can react selectively with biomolecules in living cells and organisms …

Targeting RNAs using small molecules is an emerging field of medicinal chemistry and
holds promise for the discovery of efficient tools for chemical biology. MicroRNAs are …