Ultrasound treatment of neurological diseases—current and emerging applications
Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
The sheep as a large animal model for the investigation and treatment of human disorders
A Banstola, JNJ Reynolds - Biology, 2022 - mdpi.com
Simple Summary We review the value of large animal models for improving the translation of
biomedical research for human application, focusing primarily on sheep. Abstract An …
biomedical research for human application, focusing primarily on sheep. Abstract An …
Temporary disruption of the blood–brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques
N McDannold, CD Arvanitis, N Vykhodtseva… - Cancer research, 2012 - AACR
The blood–brain barrier (BBB) prevents entry of most drugs into the brain and is a major
hurdle to the use of drugs for brain tumors and other central nervous system disorders. Work …
hurdle to the use of drugs for brain tumors and other central nervous system disorders. Work …
Attenuation, scattering, and absorption of ultrasound in the skull bone
Purpose: Measured values of ultrasound attenuation in bone represent a combination of
different loss mechanisms. As a wave is transmitted from a fluid into bone, reflections occur …
different loss mechanisms. As a wave is transmitted from a fluid into bone, reflections occur …
Anisotropic complementary acoustic metamaterial for canceling out aberrating layers
In this paper, we investigate a type of anisotropic, acoustic complementary metamaterial
(CMM) and its application in restoring acoustic fields distorted by aberrating layers. The …
(CMM) and its application in restoring acoustic fields distorted by aberrating layers. The …
3D-printed adaptive acoustic lens as a disruptive technology for transcranial ultrasound therapy using single-element transducers
G Maimbourg, A Houdouin, T Deffieux… - Physics in Medicine …, 2018 - iopscience.iop.org
The development of multi-element arrays for better control of the shape of ultrasonic beams
has opened the way for focusing through highly aberrating media, such as the human skull …
has opened the way for focusing through highly aberrating media, such as the human skull …
Ultrasound for drug and gene delivery to the brain
K Hynynen - Advanced drug delivery reviews, 2008 - Elsevier
Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) has
been demonstrated with focused ultrasound exposure in animal models. Most studies have …
been demonstrated with focused ultrasound exposure in animal models. Most studies have …
Non-invasive transcranial ultrasound therapy based on a 3D CT scan: protocol validation and in vitro results
A non-invasive protocol for transcranial brain tissue ablation with ultrasound is studied and
validated in vitro. The skull induces strong aberrations both in phase and in amplitude …
validated in vitro. The skull induces strong aberrations both in phase and in amplitude …
Apparatus and method for stimulation of biological tissue
TA Wagner, UT Eden - US Patent 8,929,979, 2015 - Google Patents
4,305.402 A 12/1981 Katims 7,120,497 B2 10/2006 Ben-Haim et al. 4,503,863. A 3, 1985
Katims 7,173,130 B2 2/2007 Tsien et al. 4,535,785 A 8, 1985 van den Honert et al. 7.283 …
Katims 7,173,130 B2 2/2007 Tsien et al. 4,535,785 A 8, 1985 van den Honert et al. 7.283 …
Depth-targeted energy delivery deep inside scattering media
Diffusion makes it difficult to predict and control wave transport through a medium.
Overcoming wave diffusion to deliver energy into a target region deep inside a diffusive …
Overcoming wave diffusion to deliver energy into a target region deep inside a diffusive …