Dyspnea in COPD: new mechanistic insights and management implications

DE O'Donnell, KM Milne, MD James, JP de Torres… - Advances in …, 2020 - Springer
Dyspnea is the most common symptom experienced by patients with chronic obstructive
pulmonary disease (COPD). To avoid exertional dyspnea, many patients adopt a sedentary …

Exercise: kinetic considerations for gas exchange

HB Rossiter - Comprehensive Physiology, 2010 - Wiley Online Library
The activities of daily living typically occur at metabolic rates below the maximum rate of
aerobic energy production. Such activity is characteristic of the nonsteady state, where …

Chronic obstructive pulmonary disease: clinical integrative physiology

DE O'Donnell, P Laveneziana… - Clinics in chest …, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) is characterized by inflammatory injury to
the intrathoracic airways, lung parenchyma, and pulmonary vasculature in highly variable …

Advances in the evaluation of respiratory pathophysiology during exercise in chronic lung diseases

DE O'Donnell, AF Elbehairy, DC Berton… - Frontiers in …, 2017 - frontiersin.org
Dyspnea and exercise limitation are among the most common symptoms experienced by
patients with various chronic lung diseases and are linked to poor quality of life. Our …

[HTML][HTML] Exertional dyspnoea in COPD: the clinical utility of cardiopulmonary exercise testing

DE O'Donnell, AF Elbehairy, A Faisal… - European …, 2016 - Eur Respiratory Soc
Activity-related dyspnoea is often the most distressing symptom experienced by patients with
chronic obstructive pulmonary disease (COPD) and can persist despite comprehensive …

Lung hyperinflation in COPD: applying physiology to clinical practice

DE O'Donnell, KA Webb, JA Neder - COPD Research and Practice, 2015 - Springer
In chronic obstructive pulmonary disease (COPD), worsening expiratory flow limitation
together with alteration in the elastic properties of the lung are associated with progressive …

Transcutaneous neuromuscular electrical stimulation: influence of electrode positioning and stimulus amplitude settings on muscle response

M Gobbo, P Gaffurini, L Bissolotti, F Esposito… - European journal of …, 2011 - Springer
The aim of the study was to investigate the influence of two different transcutaneous
neuromuscular electrical stimulation procedures on evoked muscle torque and local tissue …

The pathophysiology of dyspnea and exercise intolerance in chronic obstructive pulmonary disease

DE O'Donnell, MD James, KM Milne… - Clinics in chest …, 2019 - chestmed.theclinics.com
In the last American Thoracic Society (ATS) statement, dyspnea was defined as “a subjective
experience of breathing discomfort that consists of qualitatively distinct sensations that vary …

Recent advances in COPD: pathophysiology, respiratory physiology and clinical aspects, including comorbidities

A Bourdin, PR Burgel, P Chanez… - European …, 2009 - Eur Respiratory Soc
Owing to its major and better recognised burden from both individual and societal
perspectives, chronic obstructive pulmonary disease (COPD) is an area of intensive …

Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease

GR Chiappa, F Queiroga Jr, E Meda… - American journal of …, 2009 - atsjournals.org
Rationale: Normoxic heliox (mixture of 79% He and 21% O2) may enhance exercise
tolerance in patients with chronic obstructive pulmonary disease (COPD). It remains to be …