Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Cellular mechanisms of aortic aneurysm formation

RA Quintana, WR Taylor - Circulation Research, 2019 - Am Heart Assoc
Aortic aneurysms are a common vascular disease in Western populations that can involve
virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than …

Neutrophil extracellular traps and their implications in cardiovascular and inflammatory disease

J Klopf, C Brostjan, W Eilenberg… - International journal of …, 2021 - mdpi.com
Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis
and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) …

Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms

H Lu, W Du, L Ren, MH Hamblin… - Journal of the …, 2021 - Am Heart Assoc
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Immune and inflammatory mechanisms of abdominal aortic aneurysm

AC Marquez-Sanchez, EK Koltsova - Frontiers in immunology, 2022 - frontiersin.org
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …

AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Novel role of IL (Interleukin)-1β in neutrophil extracellular trap formation and abdominal aortic aneurysms

AK Meher, M Spinosa, JP Davis, N Pope… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Neutrophils promote experimental abdominal aortic aneurysm (AAA) formation
via a mechanism that is independent from MMPs (matrix metalloproteinases). Recently, we …

Extracellular DNA NET-works with dire consequences for health

N Sorvillo, D Cherpokova, K Martinod… - Circulation …, 2019 - Am Heart Assoc
Neutrophils play a central role in innate immune defense. Advances in neutrophil biology
have brought to light the capacity of neutrophils to release their decondensed chromatin and …