Osteochondral tissue engineering: The potential of electrospinning and additive manufacturing

AM Gonçalves, A Moreira, A Weber, GR Williams… - Pharmaceutics, 2021 - mdpi.com
The socioeconomic impact of osteochondral (OC) damage has been increasing steadily
over time in the global population, and the promise of tissue engineering in generating …

Chondroprotective and osteogenic effects of silk-based bioinks in developing 3D bioprinted osteochondral interface

JC Moses, T Saha, BB Mandal - Bioprinting, 2020 - Elsevier
Attributing cell instructive features and multifunctionality to biological inks (bioinks)
employed for three-dimensional (3D) printing strategies is very much essential to bring …

Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model

H Markides, KJ Newell, H Rudorf, LB Ferreras… - Stem cell research & …, 2019 - Springer
Background Osteochondral injuries represent a significant clinical problem requiring novel
cell-based therapies to restore function of the damaged joint with the use of mesenchymal …

Patient-reported outcomes following platelet-rich plasma injections in treating osteochondral lesions of the talus: a critically appraised topic

SF Jazzo, D Scribner, S Shay… - Journal of sport …, 2018 - journals.humankinetics.com
Clinical Scenario: Osteochondral lesions (OCLs) of the talus can result from ankle sprains
which are the most common injury in the physically active. Recently, platelet-rich plasma …

Preparation of gamma poly-glutamic acid/hydroxyapatite/collagen composite as the 3D-printing scaffold for bone tissue engineering

TT Nguyen, CC Hu, R Sakthivel, SC Nabilla… - Biomaterials …, 2022 - spj.science.org
Background All types of movements involve the role of articular cartilage and bones. The
presence of cartilage enables bones to move over one another smoothly. However …

Engineering a multiphasic, integrated graft with a biologically developed cartilage–bone interface for osteochondral defect repair

X Nie, YJ Chuah, P He, DA Wang - Journal of Materials Chemistry B, 2019 - pubs.rsc.org
Tissue engineering is a promising approach to repair osteochondral defects, yet successful
reconstruction of different layers in an integrated graft, especially the interface remains …

Clinical trials and management of osteochondral lesions

CA Vilela, A da Silva Morais, S Pina, JM Oliveira… - Osteochondral Tissue …, 2018 - Springer
Osteochondral lesions are frequent and important causes of pain and disability. These
lesions are induced by traumatic injuries or by diseases that affect both the cartilage surface …

Osteochondral tissue cultures: Between limits and sparks, the next step for advanced in vitro models

M Maglio, M Tschon, L Sicuro, R Lolli… - Journal of Cellular …, 2019 - Wiley Online Library
The increasing demand for reliable preclinical models and to reduce, refine and, if possible,
replace animal studies have brought forth the development of complex tissue cultures in …

Bilateral osteochondral defects of the patellae in an 11-year-old girl

MR Ruiz, I Igah, F Iranpour, A Patel - BMJ Case Reports CP, 2021 - casereports.bmj.com
Osteochondral defect or osteochondritis dissecans (OCD) of the knee usually affects young,
active populations. It is a challenging diagnosis as patients typically present with poorly …

Advances for treatment of knee OC defects

M Ondrésik, JM Oliveira, RL Reis - Osteochondral Tissue Engineering …, 2018 - Springer
Osteochondral (OC) defects are prevalent among young adults and are notorious for being
unable to heal. Although they are traumatic in nature, they often develop silently. Detection …