The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …

Trypanosoma cruzi, the causative agent of Chagas′ disease, which affects a large number
of individuals in Central and South America, is transmitted to vertebrate hosts by blood …

When trypomastigotes of T. cruzi emerge from cells of the mammalian host, they contain little
or no sialic acids on their surfaces. However, rapidly upon entering the circulation, they …

The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which
contribute to parasite protection and to the establishment of a persistent infection. Their …

Several types of pathogens gain entry into host cells through interactions involving sialic
acid and sialidases. In Trypanosoma pathogens, the operative enzyme is trans-sialidase …

Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on
a series of events involving interactions of diverse parasite molecules with host components …

The protozoan parasite, Trypanosoma cruzi, causes the Chagas' disease in humans through
infection of mammalian cells in both vertebrate and invertebrate hosts. Transmission of the …

Trypanosoma cruzi expresses at its surface large amounts of mucin-like glycoproteins. The
T. cruzi mucins (TcMUC), a group of highly glycosylated GPI-anchored proteins rich in Thr …

We have previously shown that 35-and 50-kDa glycoconjugates of cultured metacyclic
trypomastigotes participate in the attachment of parasites to mammalian cells. Here we show …

Mammalian cell invasion by the protozoan pathogen Trypanosoma cruzi is critical to its
survival in the host. To promote its entry into a wide variety of non‐professional phagocytic …