Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Prodrug approaches represent an excellent solution to certain pharmaceutical issues
commonly encountered in the drug discovery and development process. Along this line, the …

Polymers that release functional small molecules under mechanical stress potentially serve
as next-generation materials for catalysis, sensing, and mechanochemical dynamic therapy …

Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …

Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …

Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …

Carbon monoxide has shown promise as a therapeutic agent against cancers. Reactive
oxygen species (ROS)-activated CO prodrugs are highly demanded for targeted cancer …

Background Endogenous gasotransmitters are small gaseous mediators that can be
generated endogenously by mammalian organisms. The dysregulation of the …