The quest for targetable pain mechanisms in 2024

N Basu - Nature Reviews Rheumatology, 2024 - nature.com
The quest for targetable pain mechanisms in 2024 | Nature Reviews Rheumatology Skip to
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Role of Neural Circuits in Cognitive Impairment

L Zhang, G Liu, Y Peng, J Gao, M Tian - Neurochemical Research, 2025 - Springer
Cognitive impairment refers to abnormalities in learning, memory and cognitive judgment,
mainly manifested as symptoms such as decreased memory, impaired orientation and …

Opioidergic activation of the descending pain inhibitory system underlies placebo analgesia

H Neyama, Y Wu, Y Nakaya, S Kato, T Shimizu… - Science …, 2025 - science.org
Placebo analgesia is caused by inactive treatment, implicating endogenous brain function
involvement. However, the neurobiological basis remains unclear. In this study, we found …

Increased levels of Escherichia-Shigella and Klebsiella in the gut contribute to the responsivity of placebo analgesia

S Yang, Y Wang, Z Wu, D Wang, X Zhang, S Hu… - …, 2024 - Elsevier
Placebo analgesia is observed in both humans and animals. Given the complexity of
placebo analgesia involving a variety of neurobiological, psychological, and psychosocial …

Placebo effect involves unexpected brain regions

JS Mogil - 2024 - nature.com
Placebo effect involves unexpected brain regions Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Brain and body: Implanting a placebo in the brain to alleviate pain

J Kong - Current Biology, 2024 - cell.com
Placebo analgesia is well documented in human populations but remains relatively under-
researched in rodent models. Now researchers have engineered robust circuit-based …

Going Beyond Medications for Chronic Pain: Exploring the Alternatives

S Patidar, L LaRowe, A Goetzinger… - Policy Insights from …, 2025 - journals.sagepub.com
Chronic pain is prevalent in the US and a major source of disability. Americans are familiar
with, and often reliant on, pharmacologic interventions for analgesia. However …

[PDF][PDF] A Modern View of Placebo Interventions: From Comparative Clinical Trials to Novel Therapies to Quantum Tunnelling

SK Niazi - Preprints: Preprints, 2024 - preprints.org
The placebo effect can induce neurological and organic responses, physiological or clinical,
despite receiving no active ingredients, based on the perceptions of the recipient. The …

[HTML][HTML] Placebo Effects: Neurological Mechanisms Inducing Physiological, Organic, and Belief Responses—A Prospective Analysis

SK Niazi - Healthcare, 2024 - mdpi.com
The placebo effect can induce physiological or clinical neurological and organic responses
despite the recipient receiving no active ingredients; these responses are based instead on …

Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind

E Alway, N Reicher, DV Bohórquez - Genes & Development, 2024 - genesdev.cshlp.org
The study of biological mechanisms, while crucial, cannot fully explain complex phenomena
like the instinct to eat. The mind–body connection, as exemplified by the concept of “voodoo …