Phosphoinositides (PI s) form a minor class of phospholipids with crucial functions in cell
physiology, ranging from cell signalling and motility to a role as signposts of compartmental …

All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

Centronuclear myopathy (CNM) is an inherited neuromuscular disorder characterised by
clinical features of a congenital myopathy and centrally placed nuclei on muscle biopsy. The …

Recent studies of the low abundant signaling lipid, phosphatidylinositol 3, 5‐bisphosphate
(PI (3, 5) P2), reveal an intriguingly diverse list of downstream pathways, the intertwined …

Endoplasmic reticulum (ER) membrane contact sites (MCSs) are crucial regulatory hubs in
cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis …

Inositol lipids have emerged as universal lipid regulators of protein signaling complexes in
defined membrane compartments. The number of protein modules that are known to …

In eukaryotic cells, phosphatidylinositol is subject to differential phosphorylation, resulting in
the production of seven distinct phosphatidylinositol phosphates, often referred to as …

Professional phagocytes provide immunoprotection and aid in the maintenance of tissue
homeostasis. They perform these tasks by recognizing, engulfing and eliminating pathogens …

Polyphosphoinositides (PPIn) are low-abundance membrane phospholipids that each bind
to a distinctive set of effector proteins and, thereby, regulate a characteristic suite of cellular …

Ubiquitination serves as a key sorting signal in the lysosomal degradation of endocytosed
receptors through the ability of ubiquitinated membrane proteins to be recognized and …