Identification of constrained sequence elements across 239 primate genomes
Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
Human–chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution
D Gokhman, RM Agoglia, M Kinnebrew, W Gordon… - Nature …, 2021 - nature.com
Gene regulatory divergence is thought to play a central role in determining human-specific
traits. However, our ability to link divergent regulation to divergent phenotypes is limited …
traits. However, our ability to link divergent regulation to divergent phenotypes is limited …
Prime time for primate functional genomics
Functional genomics research is continually improving our understanding of genotype-
phenotype relationships in humans, and comparative genomics perspectives can provide …
phenotype relationships in humans, and comparative genomics perspectives can provide …
Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals
Gene regulatory elements drive complex biological phenomena and their mutations are
associated with common human diseases. The impacts of human regulatory variants are …
associated with common human diseases. The impacts of human regulatory variants are …
Diverse gene regulatory mechanisms alter rattlesnake venom gene expression at fine evolutionary scales
Understanding and predicting the relationships between genotype and phenotype is often
challenging, largely due to the complex nature of eukaryotic gene regulation. A step towards …
challenging, largely due to the complex nature of eukaryotic gene regulation. A step towards …
[PDF][PDF] Evolutionary changes in the chromatin landscape contribute to reorganization of a developmental gene network during rapid life history evolution in sea urchins
Chromatin configuration is highly dynamic during embryonic development in animals,
exerting an important point of control in transcriptional regulation. Yet there exists …
exerting an important point of control in transcriptional regulation. Yet there exists …
Human gene regulatory evolution is driven by the divergence of regulatory element function in both cis and trans
Gene regulatory divergence between species can result from cis-acting local changes to
regulatory element DNA sequences or global trans-acting changes to the regulatory …
regulatory element DNA sequences or global trans-acting changes to the regulatory …
Chromatin activity identifies differential gene regulation across human ancestries
Background Current evidence suggests that cis-regulatory elements controlling gene
expression may be the predominant target of natural selection in humans and other species …
expression may be the predominant target of natural selection in humans and other species …
Hybrid epigenomes reveal extensive local genetic changes to chromatin accessibility contribute to divergence in embryonic gene expression between species
HR Devens, PL Davidson, M Byrne… - Molecular Biology and …, 2023 - academic.oup.com
Chromatin accessibility plays an important role in shaping gene expression, yet little is
known about the genetic and molecular mechanisms that influence the evolution of …
known about the genetic and molecular mechanisms that influence the evolution of …
Human Genetics: A Look in the Mirror
C McGrath - 2020 - academic.oup.com
Who are we? Where did we come from? How did we get here? Throughout the ages,
humans have sought answers to these questions, pursuing wisdom through religion …
humans have sought answers to these questions, pursuing wisdom through religion …