ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Recent pharmacogenomic/pharmacogenetic (PGx) studies have disclosed important roles
for drug transporters in the human body. Changes in the functions of drug transporters due …

Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment
of epilepsy and bipolar disorder. Adverse effects of valproic acid are rare, but hepatotoxicity …

Although the Pgp efflux transport protein is overexpressed in resected tissue of patients with
epilepsy, the presence of polymorphisms in MDR1/ABCB1 and MRP2/ABCC2 in patients …

Purpose Epilepsy is a common serious brain condition characterized by the abnormal
electrical activity of neurons. In most cases, epileptic patients respond to antiepileptic drugs …

Background: Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety
and efficacy in treating pediatric patients with various kinds of seizures. However …

Despite the best possible medication and treatment protocols, one-third of epilepsy patients
have drug resistance which is associated with an elevated risk of mortality and debilitating …

Проблема недостаточной эффективности противоэпилептических препаратов (ПЭП) и
риск возникновения клинически значимых побочных явлений является, по-прежнему …

P-glycoprotein (P-gp), encoded by the MDR1 (multidrug resistance 1) gene, involves in the
efflux of multiple compounds, such as certain antiepileptic drugs. The aim of this research …

Background: Methadone is a substrate of the permeability glycoprotein (P-gp) efflux
transporter, which is encoded by the ABCB1 (MDR1) gene. Large interindividual variability …