Objective: This study aims to investigate the impact of cardiovascular medications on the
coronary flow reserve (CFR) in patients without obstructive coronary artery disease (CAD) …

Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the
knowledge about the mechanisms and signaling pathways involved in these processes has …

Background: Despite successful restoration of epicardial vessel patency with primary
percutaneous coronary intervention, coronary microvascular injury occurs in a large …

Purpose The goal of this study was to investigate the effects of the antianginal drugs
ranolazine, nicorandil, and ivabradine on coronary microvascular function. Methods …

Introduction Coronary heart disease (CHD) remains the leading cause of mortality in China.
The treatment strategies, especially for patients with ischemic angina pectoris, are still far …

Purpose Doxorubicin-induced cardiotoxicity (DIC) is a common side effect of doxorubicin
chemotherapy, and a major mechanism of DIC is inflammation. However, no effective …

Coronary microvascular dysfunction (CMD) has emerged as an important therapeutic target
in the contemporary management of ischemic heart disease. However, due to a lack of a …

Background Nicorandil, as a selective potassium channel opener, has dual action including
coronary and peripheral vasodilatation and cardioprotective effect through ischemic …

Coronary microembolization (CME) is a common complication of percutaneous coronary
intervention (PCI) for acute coronary syndrome. It leads to myocardial apoptosis and cardiac …

Objective: Currently, there is still no effective strategy to diminish the infarct size (IS) in
patients with ST-segment elevation myocardial infarction (STEMI). According to a previous …