The evolutionarily conserved nuclear factor-κB family of transcription factors is known to
have a crucial role in rapid responses to stress and pathogens, inducing transcription of …

Splenic peripheral B‐cell development and the events regulating this functionally significant
but relatively poorly defined developmental process have become a major focus in recent …

Paclitaxel is used to treat breast cancers, but the mechanisms by which it induces apoptosis
are poorly understood. Consequently, we have studied the role of the FoxO transcription …

In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell
lines as model systems to investigate the molecular mechanisms whereby STI571 and …

Mouse gene–targeting studies have documented a central role of the p110δ isoform of
phosphoinositide 3-kinase (PI3K) in B-cell development and function. A defect in B-cell …

Myc synergizes with Ras and PI3‐kinase in cell transformation, yet the molecular basis for
this behavior is poorly understood. We now show that Myc recruits TFIIH, P‐TEFb and …

Cell cycle arrest by FoxO transcription factors involves transcriptional repression of cyclin D,
although the exact mechanism remains unclear. In this study, we used the BCR-ABL …

In the majority of aggressive tumorigenic prostate cancer cells, the transcription factor Egr1
is overexpressed. We provide new insights of Egr1 involvement in proliferation and survival …

Initiation of T-lymphocyte-mediated immune responses involves two cellular processes:
entry into the cell cycle (G0→ G1) for clonal proliferation and coordinated changes in surface …

Meningiomas are common central nervous system neoplasms that exhibit remarkably
diverse histopathology and biological behavior. Compared to astrocytomas, the most …