Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is
used for recycling cytoplasm to generate macromolecular building blocks and energy under …

Ubiquitination has long been recognised as a key determinator of protein fate by tagging
proteins for proteasomal degradation. Most recently, the ability of conjugated ubiquitin …

The formation of the autophagosome, a landmark event in autophagy, is accomplished by
the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in …

Eukaryotic cells employ autophagy to degrade damaged or obsolete organelles and
proteins. Central to this process is the formation of autophagosomes, double-membrane …

Autophagy is a highly conserved cellular degradation process in which portions of cytosol
and organelles are sequestered into a double-membrane vesicle, an autophagosome, and …

Ubiquitination is the hallmark of protein degradation by the 26S proteasome. However, the
proteasome is limited in its capacity to degrade oligomeric and aggregated proteins …

Autophagy refers to a group of processes that involve degradation of cytoplasmic
components including cytosol, macromolecular complexes, and organelles, within the …

The autophagy factor ATG12~ ATG5 conjugate exhibits E3 ligase–like activity which
facilitates the lipidation of members of the LC3 family. The crystal structure of the human …

Plants have developed sophisticated mechanisms to survive when in unfavorable
environments. Autophagy is a macromolecule degradation pathway that recycles damaged …