Targeting oxidative stress in preeclampsia

D Afrose, S Alfonso-Sánchez… - Hypertension in …, 2025 - Taylor & Francis
Preeclampsia is a complex condition characterized by elevated blood pressure and organ
damage involving kidneys or liver, resulting in significant morbidity and mortality for both the …

Metabolic theory of preeclampsia: Implications for maternal cardiovascular health

MM Manoharan, GC Montes… - American Journal …, 2024 - journals.physiology.org
Preeclampsia (PE) is a multisystemic disorder of pregnancy that not only causes perinatal
mortality and morbidity but also has a long-term toll on the maternal and fetal cardiovascular …

A comparison of rat models that best mimic immune-driven preeclampsia in humans

F Jahan, G Vasam, Y Cariaco, A Nik-Akhtar… - Frontiers in …, 2023 - frontiersin.org
Preeclampsia (PE), a hypertensive pregnancy disorder, can originate from varied etiology.
Placenta malperfusion has long been considered the primary cause of PE. However, we and …

Placental mitochondrial impairment and its association with maternal metabolic dysfunction

A Grismaldo R, LA Luévano‐Martínez… - The Journal of …, 2024 - Wiley Online Library
The placenta plays an essential role in pregnancy, leading to proper fetal development and
growth. As an organ with multiple physiological functions for both mother and fetus, it is a …

Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications

M Palomo, AB Moreno-Castaño, MQ Salas… - Frontiers in …, 2023 - frontiersin.org
The endothelium is a biologically active interface with multiple functions, some of them
common throughout the vascular tree, and others that depend on its anatomical location …

Fetal and obstetrics manifestations of mitochondrial diseases

A Adelizzi, A Giri, A Di Donfrancesco, S Boito… - Journal of translational …, 2024 - Springer
During embryonic and neonatal development, mitochondria have essential effects on
metabolic and energetic regulation, shaping cell fate decisions and leading to significant …

Impacts of tolylfluanid on implantation and placental development: Disruption of mitochondrial function and implantation-related gene expression in vitro and in vivo

M Kim, W Park, W Lim, G Song, S Park - Science of the Total Environment, 2024 - Elsevier
Tolylfluanid is a widely used pesticide and antifouling agent in agricultural and marine
industries and is recognized as a potential endocrine disruptor. However, the toxicological …

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

W Tong, BJ Allison, KL Brain, OV Patey… - The Journal of …, 2025 - Wiley Online Library
The mechanisms that drive placental dysfunction in pregnancies complicated by hypoxia
and fetal growth restriction remain poorly understood. Changes to mitochondrial respiration …

Identification and verification of diagnostic biomarkers based on mitochondria-related genes related to immune microenvironment for preeclampsia using machine …

P Huang, Y Song, Y Yang, F Bai, N Li, D Liu… - Frontiers in …, 2024 - frontiersin.org
Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality
worldwide. Preeclampsia is linked to mitochondrial dysfunction as a contributing factor in its …

Association of Blood Manganese and Preeclampsia: A Systematic Review and Meta-analysis

A Wu, J Li, J Yuan, N Zhang, Y Zhang, M Li… - Biological Trace Element …, 2024 - Springer
A systematic review and meta-analysis was performed to comprehensively evaluate the
association between manganese (Mn) level and preeclampsia (PE) during pregnancy …