The role of fibrosis in the pathophysiology of muscular dystrophy

F Mogharehabed, MP Czubryt - American Journal of …, 2023 - journals.physiology.org
Muscular dystrophy exerts significant and dramatic impacts on affected patients, including
progressive muscle wasting leading to lung and heart failure, and results in severely …

Mitochondria and Reactive Oxygen Species: The Therapeutic Balance of Powers for Duchenne Muscular Dystrophy

SR Casati, D Cervia, P Roux-Biejat, C Moscheni… - Cells, 2024 - mdpi.com
Duchenne muscular dystrophy (DMD) is a genetic progressive muscle-wasting disorder that
leads to rapid loss of mobility and premature death. The absence of functional dystrophin in …

N-acetylcysteine alleviates oxidative stress and apoptosis and prevents skeletal muscle atrophy in type 1 diabetes mellitus through the NRF2/HO-1 pathway

Q Ding, B Sun, M Wang, T Li, H Li, Q Han, J Liao… - Life sciences, 2023 - Elsevier
Aims Type 1 diabetes mellitus (T1DM) has been linked to the occurrence of skeletal muscle
atrophy. Insulin monotherapy may lead to excessive blood glucose fluctuations. N …

What nutraceuticals can do for Duchenne muscular dystrophy: lessons learned from amino acid supplementation in mouse models

B De Paepe - Biomedicines, 2023 - mdpi.com
Duchenne muscular dystrophy (DMD), the severest form of muscular dystrophy, is
characterized by progressive muscle weakness with fatal outcomes most often before the …

[HTML][HTML] Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.

AI Rojo, B Buttari, S Cadenas, AR Carlos, A Cuadrado… - Redox Biology, 2024 - Elsevier
Non-communicable chronic diseases (NCDs) are most commonly characterized by age-
related loss of homeostasis and/or by cumulative exposures to environmental factors, which …

N-Acetylcysteine Alleviates Impaired Muscular Function Resulting from Sphingosine Phosphate Lyase Functional Deficiency-Induced Sphingoid Base and Ceramide …

M Liu, Y You, H Zhu, Y Chen, Z Hu, J Duan - Nutrients, 2024 - mdpi.com
Sphingosine-1-phosphate lyase (SPL) resides at the endpoint of the sphingolipid metabolic
pathway, catalyzing the irreversible breakdown of sphingosine-1-phosphate. Depletion of …

Chronic N‐acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy

MN Maxwell, AL Marullo… - Experimental …, 2024 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is characterised by respiratory muscle injury,
inflammation, fibrosis and weakness, ultimately culminating in respiratory failure. The …

[PDF][PDF] NATURAL DRUG INTERVENTIONS FOR DUCHENNE MUSCULAR DYSTROPHY: A REVIEW

DA El Ghifari, S Fan, H Tong, Z Jiang, L Zhang - 2023 - wjpr.s3.ap-south-1.amazonaws.com
ABSTRACT Duchenne Muscular Dystrophy (DMD) is a severe issue in the field of
neuromuscular disorders, needing novel treatment strategies. Natural substances with …

[引用][C] Mitochondrial Ca2+ handling properties in RyR1-associated myopathies

R Gaglianone De Brito - 2025 - espace.library.uq.edu.au
The skeletal muscle is pivotal for conferring and regulating movement, posture, and body
heat. Within the muscle fibres, the sarcoplasmic reticulum-mitochondria interaction is …